Spinal Circuits Transmitting Mechanical Pain and Itch
نویسندگان
چکیده
منابع مشابه
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Pain information processing in the spinal cord has been postulated to rely on nociceptive transmission (T) neurons receiving inputs from nociceptors and Aβ mechanoreceptors, with Aβ inputs gated through feed-forward activation of spinal inhibitory neurons (INs). Here, we used intersectional genetic manipulations to identify these critical components of pain transduction. Marking and ablating si...
متن کاملTransmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control
The original formulation of Gate Control Theory (GCT) proposed that the perception of pain produced by spinal cord signaling to the brain depends on a balance of activity generated in large (nonnociceptive)- and small (nociceptive)-diameter primary afferent fibers. The theory proposed that activation of the large-diameter afferent "closes" the gate by engaging a superficial dorsal horn interneu...
متن کاملUnravelling Spinal Circuits of Pain and Mechanical Allodynia
How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underl...
متن کاملChronic Mechanical Spinal Pain Syndromes
a Associate Pro Medicine, James Australia. b Adjunct Asso Tropical Medicine land, Australia. Sources of supp ment Health Depa Submit requests Box 880, Indooroo (e-mail: lggiles@a 0161-4754/$30. Copyright D 20 doi:10.1016/j.jm Objective: To assess the long-term benefits of medication, needle acupuncture, and spinal manipulation as exclusive and standardized treatment regimens in patients with ch...
متن کاملItch and pain.
The discovery of a specialized neuronal pathway for itch has markedly improved our understanding of itch processing under physiological conditions. However, the complex interactions of pain and itch are only partly understood. This review focuses on the neurophysiological mechanisms involved in clinical and experimental itch conditions. There is emerging evidence that similar patterns of periph...
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ژورنال
عنوان ژورنال: Neuroscience Bulletin
سال: 2017
ISSN: 1673-7067,1995-8218
DOI: 10.1007/s12264-017-0136-z